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Gut inflammasome activation shows close NAFLD association (93), and combined L-carnitine and vitamin E supplementation upregulated gut inflammasome-related genes while ameliorating liver inflammation and fibrosis in a NASH mouse model (94)
This difference may be attributed to variations in transcript composition, particularly the enrichment of nascent RNAs in which RNA Polymerase II (Pol II) has not yet completed transcription of the full 3 untranslated region (UTR), as well as insufficient m 6 A demethylation during transcription

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