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Previously, we established a solid-phase synthesis process for BPC157 (Xue et al., 2004) and verified its biological activity in rat gastric ulcer models and various skin wound models (Huang et al., 2015)

We also discuss the reasons for the poor efficacy of opioids, given the commonness of opioid tolerance caused by NP and/or repeated opioid treatments, an angle that has received little attention to date

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