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Deletion of Mat1a in mice resulted in depleted liver SAMe levels and reduced GSH levels, hypermethioninemia, marked changes in the expression of many enzymes of Met metabolism, and increased expression of many acute-phase markers and growth-related genes (57)
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Besides the common catalytic core, DUOX1/2 contains an EF-hand domain but, unlike NOX5, with two EF-hand motifs instead of four and a N-terminal extracellular peroxidase-homology domain

Dual-targeted mitophagy activation by curcumin-Zn co-delivery mediates neuroprotection in zebrafish through coordinated PINK1/Parkin and PI3K/AKT/mTOR pathway regulation

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