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Nature 579:427432 Hamanaka RB, Chandel NS (2009) Mitochondrial reactive oxygen species regulate hypoxic signaling

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Cell protection: It helps neutralize free radicals, thus reducing oxidative stress and protecting cells from damage

In a previous study, transcriptomic profiling of brain regions involved in the brains reward circuitry (prefrontal cortex, dorsal striatum, nucleus accumbens, basolateral amygdala, ventral hippocampus, and ventral tegmental area) revealed considerable changes in transcript expression during the cocaine self-administration, withdrawal, and relapse phases, with the greatest changes detected in the re-exposure phase 40

We would not advise that women consume L-citrulline, an alternative form of L-arginine, because it has not been sufficiently studied in the female population