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Zepbound is approved for chronic weight management and a sleep disorder called obstructive sleep apnea

Fermented beverage and food storage in 13,000 y-old stone mortars at Raqefet Cave, Israel: Investigating Natufian ritual feasting

Its main product, ADPR, can either be metabolized by the CD203a/CD73 exoenzymatic tandem into ADO (40), which binds to purinergic type 1 (P1) receptors (particularly A2A and A2B), or facilitate Ca2+ influx through TRPM2 channels (45)
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