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To bridge this gap, the field needs to pursue advanced lipidomic profiling using patient biofluids (such as cerebrospinal fluid and plasma) to identify and quantify the specific oxidized PUFA species (e.g., oxPEs) that represent the ultimate executioners of the ferroptotic cascade [55,104]

Its mechanism of action follows a clear pathway hierarchy and gene dependency: On one hand, Tripterygium wilfordii extract enhances cellular antioxidant defenses by activating the transcription factor Nrf2

[DOI] [PubMed] [Google Scholar] 14.Zamponi E., Zamponi N., Coskun P., et al

In MS, the application of ferroptosis inhibitors has shown promise in reducing neurodegeneration (90)