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Even more importantly, low DPI scores were also related to metabolic dysfunction as defined by elevated C reactive protein (CRP) and insulin resistance

whereas primitive birds, reptiles, and amphibia create GULO in the kidney, mammals and highly evolved birds manufacture it in the liver [2,17]

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doi: 10.1016/j.jnutbio.2018.09.024 145

In order to investigate the relationship between metformin and the microbiota, one group of researchers developed a modulator of the microbiome to attempt to shift the GI microflora of that observed in T2DM to one more typical of healthy individuals