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mtDNA is more susceptible to damage (including mutations) than nuclear DNA, likely due to a lack of histones to protect the DNA from damage, the proximity of mtDNA to ROS production, limited DNA repair systems, limited proofreading capacity during replication, and ROS, reactive nitrogen species, and other products produced in the mitochondria that can damage the DNA

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Electron transport chain defects in Alzheimers disease brain

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