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While the exact causative mechanism isnt always clear, high dose opioid use can lead to rhabdomyolysis, which can increase the risk of acute renal failure and death

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This means getting as close to 100% of normal thyroid function as you possibly can

doi: 10.1016/j.cmet.2010.05.001 113 KappelerL.De Magalhaes FilhoC.DupontJ.LeneuveP.CerveraP.PrinL.et al
And many people do
