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When (R)-4-chloro-3-hydroxy butyric acid alkyl ester was prepared by the hydrolysis of racemic 4-chloro- 3 -hydroxy butyric acid alkyl ester in an aqueous solution or an aqueous solution-containing solvent using immobilized lipase, the reaction product was extracted with ethyl acetate and analyzed by gas chromatography (Model No

10.1016/S0140-6736(80)91773-0 Khoo SH, Leyland MJ: Cerebral edema following acute sodium valproate overdose

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