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This section covers what is known about safety along with theoretical concerns

Diamide-induced alterations of intracellular thiol status and the regulation of glucose metabolism in the developing rat conceptus in vitro

Certain medications The following drugs can reduce levels of vitamin B12 in your body: Antibiotics -- long-term use can lower vitamin B levels generally Anti-seizure drugs Chemotherapy medicines, especially methotrexate Drugs used to reduce stomach acid, like H2 blockers (Pepcid AC, Tagamet, Zantac) and proton pump inhibitors (Nexium, Prevacid, Prilosec) Metformin (Glucophage) -- taken for diabetes Colchicine -- taken for gout Some cholesterol-lowering medications Other causes You're over 65

Full specifications and reference information are maintained in the official Pfizer labeling document: Pfizer Labeling (Official Document)

N-acetylcysteine (NAC) is a stable cysteine derivative that is known to help you produce reduced glutathione, and is widely available as a supplement