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doi: 10.1159/000129686
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Hawkins, M
Mechanistically, alterations in gut microbial metabolites such as SCFAs could affect the integrity of the BBB, induce systemic endotoxemia, and activate microglia so as to impact disease progression
Thus, creatine has evolved from a phosphate shuttle to a systemic metabolic orchestrator , integrating energy sensing (AMPK/mTOR), allocation (mitochondrial networking), and dissipation (futile cycling)
