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While the induction of the MPTP has been considered to be a catastrophic feature of APAP-induced cell signaling, recent research suggests that this too could be adjusted depending on the dose of APAP, where treatment of animals with a low 150-mg/kg overdose of APAP resulted in transient JNK activation and reversible induction of the MPTP20, from which cells may be able to recover

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Scheduled breaks or cyclic protocols are often used to reduce that risk, but individual response is highly variable