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Cancer Res 62:51965203 Thor H, Smith MT, Hartzell P et al (1982) The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes
As robust preclinical safety data and expanded clinical evidence from repurposed nanomedicines accumulate, establishing refined regulatory standards will be crucial
If urgent use of an opioid is necessary, use test doses and frequent titration of small doses to treat pain while closely monitoring blood pressure and signs and symptoms of CNS and respiratory depression
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