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Indeed, as Lefkovits and Waldmann argue, 'As long as antibody was thought of as a single molecular species that could adapt and adjust to any antigen, then there was no incentive to search for a cellular basis.' They assert that it was only after Burnet '(1957) postulated 1 cell = 1 antibody, and after Gowans (1963) showed that it was the lymphocyte which represented the basic functional unit of the immune system, did the revolution in the methodology of cellular assays become possible' (Lefkovits, Waldmann, 1979)

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Nelson DB, Godoy MC, Benveniste MF, Shewale JB, Spicer JD, Mitchell KG, Hofstetter WL, Mehran RJ, Rice DC , Sepesi B, Walsh GL, Vaporciyan AA, Swisher SG, Roth JA, Antonoff MB