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Given its origin in glycolytic processes, many studies have shown a dynamic link between lactate metabolism and HIF-1: under low oxygen conditions, HIF-1 attaches to the VEGF promoter, activating its gene expression [168]

Natural Science Youth Fund of Hebei Province Education Department (QN2020167)

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However, comprehensive clinical studies including the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and European First-Episode Schizophrenia Trial (EUFEST), revealed no clear advantages of atypical over typical drugs in terms of efficacy (Lieberman et al., 2005