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Topiramate can induce cytochrome P450 (CYP) 3A4 and inhibit CYP2C19
At ED12.5 Grx3 / embryos show no obvious histological abnormalities but are smaller than wild type embryos and later develop haemorrhages in the head
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Common KD adverse effects include metabolic abnormalities, gastrointestinal symptoms, kidney stones, and slow growth in children (232)
The injection should be administered only under medical supervision
