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Oxidative stress is thought to cause liver disease

Regulatory status (US) Not FDA-approved Category 2 (2023) PCAC July 2026 Compound Melatonin What it is Hormone supplement Mechanism (in plain English) Shifts sleep timing via the circadian system

However, the majority of cases are mild ( Figure 1F ) and progress towards cure ( Figure 1G )

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One RCT ( n =67) reported decreased levels of fasting glucose following supplementation compared with placebo [238], while another ( n =51) which used a lower dose (1000 mg/day versus 1500 mg/day) and shorter duration (six weeks versus 12 weeks), reported no between group differences for fasting glucose, HOMA-IR or lipids [239]