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Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulatordependent bicarbonate secretion
doi: 10.1517/17425247.2.4.683
Disadvantages comprise higher risk of particle aggregation and toxicity

Peripheral blood was obtained from patients who providedwritten informed consent as part of a protocol approved by theInstitutional Review Board of The University of Texas MDAnderson Cancer Center and in accordance with the Declarationof Helsinki

Additionally, repeated freeze-thaw cycles are particularly damaging to metal-peptide complexes because the copper(II) ion can catalyze oxidative damage to the histidine imidazole ring during the transient concentration spikes that occur at ice-liquid interfaces
