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It is known that reduction in CD38 expression on BM and circulating MM cells occurs rapidly after daratumumab initiation with significantly lower expression levels after the first infusion compared with baseline (potentially due to elimination of MM cells with high CD38 levels, endocytosis, or release in microvesicles), that may persist for at least 6 months after discontinuation [35]

Once your personalized plan is set, a nurse will clean the injection site (typically the arm or glute) and administer your shot using a sterile syringe and needle