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Recent evidence in rodent models has demonstrated that neutralizing mtDNA with the nucleic acid scavengers such as hexadimethrine bromide (HDMBr) could reduce the severity of multi-organ dysfunction and may improve survival [46]

10.1139/gen-2015-0124 4 Adihe LokangaR.ZhaoX.-N.EntezamA.UsdinK

Furthermore, human Fanconi Anaemia patients carrying a mutation in the gene coding for the acetaldehyde/FA catabolizing enzyme aldehyde dehydrogenase 2 (ALDH2) present accelerated progression of bone marrow failure (BMF) 13

A review of the antioxidant mechanisms of polyphenol compounds related to iron binding

Heumann R, Moratalla R, Herrero MT, Chakrabarty K, Drucker-Coln R, Garcia-Montes JR, et al