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TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle
This metabolic shift rapidly depletes cellular glycogen reserves, generates excessive lactic acid, and leads to the crushing, unyielding fatigue that characterizes the Long COVID experience
People who are pregnant, breastfeeding, diagnosed with any illness, or taking any medications must consult with a healthcare professional first
