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Therefore, for drugs like doxorubicin or cisplatin to achieve therapeutic efficacy, they must first be released from the liposomal carrier into the tumor microenvironment and subsequently diffuse across the cellular membrane into the intracellular space [103]

Finally, in phase III, the conjugated xenobiotics may be further processed, before being recognised by efflux transporters and pumped out of cells

They are not protected by toxic substances or bacteriophages

We have demonstrated that during viral infections a decrease of intracellular GSH is operative that varies in intensity, duration and mechanism of induction depending on the type of virus and the infected host cell ( Figure 3

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