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Mechanistic Claims

This initial period allows the body to adapt to NNMT inhibition while minimizing potential side effects

The more NNMT activity, the more your NAD+ precursors get converted into a form your cells can't use

We found that intracellular 1-MNA and NNMT protein expression levels were substantially higher in the fully differentiated adipocytes compared to the undifferentiated pre-adipocytes, which is consistent with the differentiation-dependent enhancement in NNMT mRNA levels and enzymatic activity reported previously in the 3T3-L1 cell lines.[37] The higher levels of 1-MNA and NNMT in adipocytes compared to pre-adipocytes may partially account for our observations that increasing concentrations (10 60 M) of NNMT inhibitor did not completely eliminate 1-MNA in adipocytes, but did fully suppress 1-MNA accumulation in undifferentiated pre-adipocytes

[DOI] [PubMed] [Google Scholar] 19.Yuan M, Breitkopf SB, Yang X, Asara JM