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RCTs offer strong internal validity through randomization, blinding, and strict eligibility criteria, while RWE provides external validity by reflecting patient diversity, long-term outcomes, and care patterns in everyday practice

Similarly, dysregulation of protein arginine methyltransferase 1 (PRMT1) and PRMT2 alters histone methylation, further driving GBM progression and therapy resistance

We further discuss emerging strategies for restoring or manipulating zinc homeostasis, as well as advanced tools for visualizing organelle-level zinc dynamics
The induction of ferroptosis continues to be explored a potential intervention strategy to the treatment of cancers (78,79)

Effects of the glucagon-like peptide-1 receptor agonist dulaglutide on sexuality in healthy men: A randomised, double-blind, placebo-controlled crossover study
