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Role of sphingosine 1-phosphate signalling in tissue fibrosis

One pivotal trial followed patients taking 600mg of racemic ALA daily for four years and found no significant safety concerns.7 We explore the differences between racemic ALA and R-ALA later in the guide, but its worth noting here: racemic ALA has the strongest long-term safety data in humans

The best choice depends on goals, health, tolerance, and budget

doi: 10.1002/ptr.6895

This is because active folate (methylfolate) is required for B12-dependent reactions, and MTHFR variants can reduce folate availability
