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However, robust clinical evidence in humans remains limited, with most published data coming from laboratory and animal studies rather than large randomized trials

The thyroid gland secretes triiodothyronine (T3) and tetraiodothyronine (thyroxine, T4)

Although several drugs are under investigation, there are currently no approved drugs for NAFLD (80)

NAD+ also plays an important role in reducing oxidation in the cells, which can decrease inflammation and help improve mitochondrial function

The search was performed in the PubMed, Web of Science, Embase, and Scopus databases for articles published from January 1, 2012, to May 31, 2025