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Description
This abnormal melanin production is known as melasma
Free Radical Biology and Medicine 187, 158170
4.1 In vitro experiments In a study conducted by An et al., using human umbilical vein endothelial cells, it was found that metformins antioxidant properties, at a dose of 2 mmol/L, were achieved through specific mechanisms
The major challenge was the exceptional hydrophobicity of the peptide segment, which was overcome by employing a solubilizing tag and optimizing the reaction conditions using hexafluoroisopropanol (HFIP) as a cosolvent

[DOI] [PubMed] [Google Scholar] [80].Boyd-Kimball D, Sultana R, Abdul HM, Butterfield DA
