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11,12 Despite the consistent results showing benefit of NADs in reducing HE and its related mortality, these RCTs did not assess the confounding effect of factors precipitating HE since strategies directed at management of precipitating factors may improve HE with or without NADs

In summary, the consumption of EDs is associated with a risk of drug interactions due to the documented potential of the most relevant components of EDs (caffeine, to a lesser extent taurine, ginseng, and Ginkgo) to enter into various interactions, both pharmacokinetic and pharmacodynamic

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