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The chiral reduction step is catalyzed by ketoreductase (KR) domains embedded in the corresponding A domains CesA1 and CesB1, respectively
Drug resistance mechanisms beyond DPP9-NRF2 (255) and AIM2-FOXO3a (258) are also underexploredwhether epigenetic modifications (e.g., DNA methylation of ACSL4), post-translational regulation (e.g., GPX4 ubiquitination), or metabolic rewiring (e.g., alternative antioxidant pathways) drives acquired resistance to ferroptosis inducers requires investigation
Due to the presence of tTG2 in tissues besides the intestines, autoimmune cross-reactions with other tissues (like the thyroid) may occur
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doi: 10.3389/fnmol.2021.657514 [DOI] [PMC free article] [PubMed] [Google Scholar] 55
