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Oberst, A

A method of expanding a population of genetically engineered T cells in a mammal diagnosed with cancer, said method comprising administering to said mammal administering to said mammal a T cell genetically modified to express a chimeric antigen receptor (CAR) according to any one of claims 88-92, wherein the administered genetically engineered T cell produces a population of progeny T cells in the human

Consistent with this concept, we examined treatment-associated transcriptional changes by stratifying samples according to treatment timing and recurrence status

Here's what the research shows: That last point is significant

This is one reason gentle handling is emphasized