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It was first characterized by Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, and a 2025 literature and patent review cataloged its effects across gastrointestinal, musculoskeletal, and neural models

The next sections discuss mechanisms, evidence, dosing factors, and safety implications for clinical and research use

Numbness and Tingling: A lack of B-12 can affect the nervous system and cause numbness and tingling in the hands and feet

Stacking : Often with GHK-Cu or Ipamorelin for enhanced repair

As per the updated NICE guidelines, Vitamin B12 deficiency is more common in older people and is thought to affect around 5% of 65-74-year-olds and over 10% of over-75s. Vegans - People who follow a diet that excludes, or is low in, animal-source foods, e.g