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Further investigations revealed that mammalian lipoxygenase family member arachidonate 12-Lipoxygenase (ALOX12) is crucial for p53-dependent ferroptosis
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Ostrand-Rosenberg S, Sinha P, Beury DW, Clements VK, Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression
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These parameters significantly influence therapeutic outcomes
