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COMT inhibitors COMT inhibitors primarily function by inhibiting COMT, thereby increasing the concentration of L-DOPA in the brain and preventing its peripheral degradation into 3-O-methyldopa (3-OMD)

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Peer review Peer review information Nature Metabolism thanks Timothy Wai and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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Because it rapidly aggregates and forms the majority of Lewy bodies (LBs), -synuclein is particularly noteworthy

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