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PD involves the progressive degeneration of dopamine-producing neurons in the substantia nigra, resulting in reduced dopamine neurotransmitter in the striatum as shown in Fig
A wash buffer is then applied to remove non-target biomolecules by disrupting their weaker interactions with the stationary phase, while the biomolecules of interest will remain bound

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This process requires the coordination of both cell division and cell identity changes among the cells that will give rise to the new, regenerated tissue

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