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The aromatic hydroxylated BI is a precursor to the quinone methide and quinone imine reactive toxic intermediates in the proposed bioactivation pathway

Brain glucose hypometabolism is reported both in older adults and in AD [43,44,45,46,47,48,49,50,51,52,53,54]

While astrocytes are especially poised for glucose uptake given that their endfeet have a high vessel coverage of 63%99% (Mathiisen et al

10.1007/978-1-4615-1833-4_48 70 LeeJ

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