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After the reduction, a second alkylation step was carried out by adding 5 l of 100 mM d5-NEM
84 Exosynaptic glutamate also contributes to metabolism in neurons and astrocytes
Positive results have also been reported from clinical trials of masitinib for the treatment of other neurological and inflammatory diseases such as rheumatoid arthritis and Alzheimers disease [315, 316]
An in vitro study suggested that necroptosis is involved in the pathogenesis of PD through excitotoxicity, the accumulation of intracellular Ca 2+ or TNF, although its contribution to PD pathology is uncertain (Beal, 2008
Accessed August 30, 2022
