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Antipychotics (both typical and atypical) have been used to manage such severe withdrawal, but they are typically used as an adjunct treatment (often administered in combination with benzodiazepines or anticonvulsants) because alone, they offer no protection against seizures

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In recent years there has been considerable interest in the therapeutic potential of L-carnitine and acetyl-L-carnitine (ALCAR) for neuroprotection [1, 4, 722]

Lastly, while APOE effects dominated brain profiles, sex effects were more prominent in the periphery, which was also in accordance with a previous study in older (16 months old) APOE-TR mice (Shang et al., 2020), suggesting that regardless of age APOE has a major effect on brain bioenergetics