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These DEGs and DEMs are involved in a variety of biological processes, such as phenylspropanoid biosynthesis and glutathione metabolism pathways
48,49 To delineate the role of BM neutrophils in this process, we employed integrated metabolomic and transcriptomic profiling and demonstrated that periodontitis triggers their polarization toward a pro-inflammatory N1 phenotype via GSH metabolic reprogramming
[DOI] [PMC free article] [PubMed] [Google Scholar] 137.Johansson M.E., Cameron I.G.M., Van der Kolk N.M., de Vries N.M., Klimars E., Toni I., Bloem B.R., Helmich R.C
