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For those contemplating participation, specific criteria must be met: Good overall health Meet the eligibility criteria Informed consent Time commitment Good overall health Healthy volunteers in clinical trials must demonstrate good overall health

Although lots of attempts have been made to improve the biocompatibility and reduce the toxicity of MnO 2 NPs, more attentions are still needed to promote the final clinic uses of MnO 2 NPs

Biomedicine 11(3):754 Havel PJ (2004) A scientific review: the role of chromium in insulin resistance

The review indicates the prospect of nanoparticle-mediated drug delivery systems in AILI treatment, such as Gal-D-NAC

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