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Active malignancy is a contraindication because NAD+ supports cellular proliferation

According to the World Obesity Federations 2025 Atlas, the number of adults living with obesity is expected to more than double from 524 million in 2010 to 1.13 billion by 2030

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PMID: 35105939 Nat Metab The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress

Patients should seek their physician for medical prescriptions, education, and health care recommendations
