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Description
No PAD activity was observed in the corresponding supernatants, but addition of exogenous GSH restored activity
To offer a semiquantitative yet predictive understanding of the mechanism, we formulate a kinetic model for the G protein signaling and desensitization by considering essential biochemical steps from ligand binding to receptor internalization
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With a nominal ambient ET exposure (15 ppb), predicted exhaled ET reaches 16 ppb, aligned with the literature
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