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Induced-fit docking of GSSG to GLRX All the protein-ligand docking was performed with the Induced Fit Docking (IFD) package 60 with the GSSG molecule minimized in solvent using DFT calculations (B3LYP-6-31G**) and QM-calculated partial charges

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GH axis stimulation in pre-clinical ageing models: Studies examining GHRH analogue + GHRP combinations in aged rodent models documented restoration of GH pulse amplitude and IGF-1 levels toward younger values with findings establishing that somatotroph GH secretory capacity is largely preserved in aged animals despite reduced hypothalamic GHRH drive, and that pharmacological dual-pathway somatotroph stimulation can overcome age-associated GH decline

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