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Future research should verify the efficacy of these novel methods through large-scale, multi-center, randomized, double-blind, and long-term follow-up RCTs, while utilizing multi-omics and big data technologies to delve into their mechanisms of action, ultimately achieving the goal of comprehensive treatment based on microbiome-based precision regulation

For UGT2B15 , the percentage of APAP-glucuronide metabolite and the ratio of APAP-gluc to free APAP is diminished, while that of APAP-sulfate increased across genotypes from *1/*1 to *2/*2 [26]

Inhibitors of STX7Munc13-4 show similar benefits but Munc13-4 is mainly expressed in hematopoietic cells

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