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First, these data suggest that it is the presence of excess APP expression, not the mutant PSEN1, that is the most likely driver of myelin abnormalities

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Because of the location of varicose veins in the lower extremity, and the increase in lower extremity venous pressure in the standing position, a relationship between the lower extremity high venous pressure and the formation of varicose veins has long been proposed

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[DOI] [PMC free article] [PubMed] [Google Scholar] 137.Schndorf DC et al