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However, work in the 1990s and during the last few years has shown that hydropersulfides are excellent hydrogen atom transfer agents, directly engaging in one-electron reactions 18,19,20 , although the exact mechanisms and their relevance to biological systems remain to be clarified

For context, human safety testing found no meaningful irritation from creams containing centella extract at everyday use levels (the tested amounts were well under 1%)

Palmieri C, Trimboli F, Puca A, Fiume G, Scala G, Quinto I: Inhibition of HIV-1 replication in primary human monocytes by the IkappaB-alphaS32/36A repressor of NF-kappaB