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The proportions of protein, fat and carbohydrate, as well as the fatty acid compositions of the control HFD diets that were used in this study are elucidated in a previous report

Testosterone replacement attenuates cognitive decline in testosterone-deprived lean rats, but not in obese rats, by mitigating brain oxidative stress

Notably, acetylcarnitine can act as an acetyl donor [37], supporting the acetylation process of cells through the shuttle mechanism of acetylcarnitine in the absence of conventional acetyl-CoA synthetase enzymes such as ATP-citrate lyase (ACLY) and acyl-CoA synthetase short chain 2 (ACSS2) [38]

A meta-analysis of 37 randomized controlled trials found approximately 2,000 mg/day oral L-Carnitine yields modest weight-loss effects (~1.2 kg), with diminishing returns above that dose [2]