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Chronic infections also increase oxidative pressure, contributing to oxidative imbalance and damage to aging cells

Proposal of new staging in advanced colorectal cancer:304, 2009
[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Wolthers K.R., Scrutton N.S

Consequently, respiratory inhibitors can impede ETC complexes, causing over-reduction in different segments of the ETC and resulting in excess superoxide production (Schwarzlnder et al., 2009)

NAC helps in overdose, where glutathione must rapidly neutralize NAPQI