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As a consequence, CpG 5 islands flanking the repeats as well as the repeats itself, which also function as a CpG island, become hypermethylated and render the gene inactive (Hansen et al., 1992)

For example, methylglyoxal, an enzymatic, and non-enzymatic product deriving from the glycolytic pathway (Martins et al., 2001

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doi: 10.1007/978-1-62703-845-4_23 [DOI] [PubMed] [Google Scholar] 133

Gene expression studies confirm direct effects on pathways controlling hair growth, and the combination of preclinical efficacy plus clinical success in topical applications supports the rationale for injectable use