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Description
Antisense oligonucleotide knockout FMO3 in mice reduced atherosclerosis, and downregulation of FMO3 not only reduced TMAO level but also regulated lipid metabolism and inflammation, thereby reducing atherosclerosis (Shih et al., 2015)
Moludi, J., Maleki, V., Jafari-Vayghyan, H., Vaghef-Mehrabany, E., & Alizadeh, M

A 2017 systematic review and meta-analysis identified 12 intervention studies that assessed the effect of L-carnitine or ALCAR on cancer-related fatigue (reported as a primary or secondary outcome) in cancer survivors (108)
Prevents cellular oxidation
In addition to its role in ATP synthesis, mitochondrial coenzyme Q 10 mediates the oxidation of dihydroorotate to orotate in the de novo pyrimidine synthesis
